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pentobarbital will lower the level or result of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can lessen panobinostat ranges by ~70% and produ